Phenotypes Associated with This Genotype

Genotype
MGI:3760003

• Allelic Composition: Wwtr1^tm1Benj/Wwtr1^tm1Benj
• Genetic Background: 129S6/SvEvTac-Wwtr1^tm1Benj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:125326 )

• only half of the expected number of mice are born

renal/urinary system

kidney cortex cyst ( J:125326 )

• mice develop severe polycystic renal disease with cysts of varying sizes scattered throughout the cortex

• cysts are bilateral, appear at day 18 at the earliest, are lined with cuboidal epithelium with scanty cytoplasm and are frequently filled with homogeneous eosinopilic fluid or small amounts of floccular material

• cysts and kidney size increase with age

• however, mice do not develop cysts in the salivary glands, pancreas, liver or other glandular organs

polycystic kidney ( J:125326 )

• mice develop severe polycystic renal disease

enlarged kidney ( J:125326 )

• kidney size increases with age

hydronephrosis ( J:125326 )

• mice exhibit dilation of the renal pelvis at a young age

respiratory system

lung inflammation ( J:125326 )

• lung inflammation is observed in some 2- to 4-week old mice

abnormal pulmonary alveolus wall morphology ( J:125326 )

• breakdown of alveolar walls

overexpanded pulmonary alveolus ( J:125326 )

• swollen alveoli

emphysema ( J:125326 )

• mice develop emphysema associated with swollen alveoli and breakdown of alveolar walls

immune system

intestinal inflammation ( J:125326 )

• intestinal inflammation is observed in some 2- to 4-week old mice

lung inflammation ( J:125326 )

• lung inflammation is observed in some 2- to 4-week old mice

adipose tissue

decreased fat cell size ( J:125326 )

• adipocytes are smaller in size than in wild-type mice

behavior/neurological

decreased locomotor activity ( J:125326 )

growth/size/body

kidney cortex cyst ( J:125326 )

• mice develop severe polycystic renal disease with cysts of varying sizes scattered throughout the cortex

• cysts are bilateral, appear at day 18 at the earliest, are lined with cuboidal epithelium with scanty cytoplasm and are frequently filled with homogeneous eosinopilic fluid or small amounts of floccular material

• cysts and kidney size increase with age

• however, mice do not develop cysts in the salivary glands, pancreas, liver or other glandular organs

polycystic kidney ( J:125326 )

• mice develop severe polycystic renal disease

decreased body size ( J:125326 )

enlarged kidney ( J:125326 )

• kidney size increases with age

digestive/alimentary system

intestinal inflammation ( J:125326 )

• intestinal inflammation is observed in some 2- to 4-week old mice