Phenotypes for Gab1 MGI:3759964 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gab1^tm1Wbm/Gab1^tm1Wbm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1^tm1Wbm mutation (0 available); any Gab1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Cleft palate in Gab1^tm3Wbm/Gab1^tm3Wbm, Gab1^tm2Wbm/Gab1^tm2Wbm, Gab1^tm1Wbm/Gab1^tm1Wbm and Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ mice, but not in Gab1^tm4Wbm/Gab1^tm4Wbm mice

craniofacial

cleft secondary palate ( J:125303 )

• at E16, many mice have an open secondary palate

muscle

abnormal skeletal muscle morphology ( J:125303 )

• extensor muscles are missing and muscles reach less far distally

decreased skeletal muscle mass ( J:125303 )

digestive/alimentary system

cleft secondary palate ( J:125303 )

• at E16, many mice have an open secondary palate

growth/size/body

cleft secondary palate ( J:125303 )

• at E16, many mice have an open secondary palate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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