Phenotypes Associated with This Genotype

Genotype
MGI:3759848

• Allelic Composition: Pax6^tm1Lan/Pax6^tm1Lan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:73524 )

• by E17.5, lens size difference compared to wild-type is reduced relative to earlier embryonic ages, but lens stalk persists

abnormal lens vesicle development ( J:73524 )

• by E10.5, lens pit is significantly smaller than wild-type, whereas at E11.5, lens vesicle is still connected to surface ectoderm and remains small

abnormal optic placode morphology ( J:73524 )

• at E9.5, regional reduction in placodal thickness is observed with surface ectoderm apposed to optic vesicle being markedly thinner; proportion of proliferating cells in this region is significantly different from wild-type

abnormal lens epithelium morphology ( J:73524 )

• lens epithelial layer remains attached to surface ectoderm (prospective corneal epithelium)

abnormal lens fiber morphology ( J:73524 )

• lens fiber cell differentiation is delayed compared to wild-type