Phenotypes Associated with This Genotype

Genotype
MGI:3759808

• Allelic Composition: Mapk1^tm1Kuta/Mapk1^tm1Kuta
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:125594 )

N • mice exhibit normal general behavior, exploration behavior, anxiety-related behaviors, locomotion, circadian rhythms and spatial working memory

abnormal contextual conditioning behavior ( J:125594 )

• after 48 hours, but not after 2 hours, retention delay contextual freezing response is reduced compared to wild-type mice

• long term, but not short term, memory in fear conditioning is impaired

abnormal cued conditioning behavior ( J:125594 )

• after 48 hours retention delay, the cued freezing response is reduced

abnormal spatial learning ( J:125594 )

• in a Morris water maze, mice exhibit increased latency to escape compared to wild-type mice on days 2 through 7 and 9 but not after day 10

• in an 8 by 8 version of the 8-arm radial maze, mice require a longer training phase up to day 5 and mice create more revisiting errors on days 2 through 4 compared to wild-type mice

• in a 4 by 8 version of the 8-arm radial maze, mice score lower than wild-type in relation to reference memory correct choices and higher in relation to reference memory error scores

• mice use a spatial search strategy rather than a nonspatial serial searching strategy

• however, working memory and motivation in the 4 by 8 version of the 8-arm radial maze is unaffected

• while spatial working memory is normal, reference memory is impaired

nervous system

nervous system phenotype ( J:125594 )

N • brain histology and dendritic spine morphology are normal