Phenotypes Associated with This Genotype

Genotype
MGI:3759672

• Allelic Composition: Sox10^tm4Weg/Sox10^tm4Weg
• Genetic Background: involves: 129P2/OlaHsd * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:124679 )

• all mice are born alive but many die within a few hours after birth

postnatal lethality, complete penetrance ( J:124679 )

• mice that survive more than 24 hours past birth die by 3 days of age

nervous system

nervous system phenotype ( J:124679 )

N • unlike in mice homozygous for Sox10^tm5Weg, lumbar dorsal root ganglion morphology and the number of myelinating oligodendrocytes are not significantly different from wild-type

N • unlike in mice homozygous for Sox10^tm1Weg, cranial and sympathetic ganglia morphology are similar to wild-type

abnormal enteric neuron morphology ( J:124679 )

• the stomach wall of E18.5 embryos contains fewer neurons and glial cells than in wild-type or Sox10^tm3(Sox8)Weg homozygous embryos

abnormal Schwann cell morphology ( J:124679 )

• expression analysis indicates that Schwann cells fail to mature to the myelinating stage by E18.5

dorsal root ganglion hypoplasia ( J:124679 )

• slight changes in shape of the dorsal root ganglion are found in E18.5 embryos

digestive/alimentary system

aganglionic megacolon ( J:124679 )

• mice that survive birth exhibit a large colon

embryo

abnormal melanoblast migration ( J:124679 )

• number of migrating melanoblasts near the eye are strongly reduced in E12.5 embryos

cellular

abnormal melanoblast migration ( J:124679 )

• number of migrating melanoblasts near the eye are strongly reduced in E12.5 embryos