Phenotypes Associated with This Genotype

Genotype
MGI:3759582

• Allelic Composition: Ednrb^s-36Pub/Ednrb^s-36Pub; Tg(Spry2)2Tpo/0
• Genetic Background: B6.Cg-Ednrb^s-36Pub Tg(Spry2)2Tpo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

craniofacial phenotype ( J:125229 )

N • transgenic mice show complete rescue of cleft lip phenotype

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

skeleton

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

digestive/alimentary system

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes

growth/size/body

abnormal palate bone morphology ( J:125229 )

• at E18.5, bones of hard palate are reduced in size and show altered morphology

maxillary shelf hypoplasia ( J:125229 )

• at E18.5, palatal processes of maxilla are reduced in size and show altered morphology

cleft secondary palate ( J:125229 )

• incidence of cleft secondary palate is reduced to 42% in non-transgenic homozygotes