Phenotypes Associated with This Genotype

Genotype
MGI:3759500

• Allelic Composition: Gfra2^tm1Jmi/Gfra2^tm1Jmi
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal enteroendocrine cell morphology ( J:125236 )

• mice have fewer synaptophysin+ enteroendocrine cells compared to wild-type mice

abnormal intestinal transit time ( J:125236 )

• basal gastrointestional transit rate is impaired by 37+/-6% compared to in wild-type mice

• administration of glucagons-like peptide-1 (GLP) and GLP-2 fail to inhibit transit rates as it does in wild-type mice

• however, there is no difference between basal of GLP-2-stimulated mucosal growth

nervous system

abnormal parasympathetic neuron morphology ( J:125236 )

• mice suffer from parasympathetic denervation

growth/size/body

decreased body weight ( J:125236 )

• body weight is decreased (16.0+/-0.8 compared to 18.2+/-0.6)

cellular

abnormal enteroendocrine cell morphology ( J:125236 )

• mice have fewer synaptophysin+ enteroendocrine cells compared to wild-type mice