Phenotypes Associated with This Genotype

Genotype
MGI:3759462

• Allelic Composition: Robo2^tm1Rilm/Robo2^tm1.1Rilm; Tg(EIIa-cre)C5379Lmgd/?
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal/urinary system morphology ( J:125214 )

• mice exhibit unilateral urinary tract abnormalities, including short ureter, megaureter, and hydronephrosis

kidney cyst ( J:125214 )

• kidney parenchyma is replaced by large cysts

hydronephrosis ( J:125214 )

• ureterovesical junctions associated with obstructions lead to megaureter and hydronephrosis

abnormal ureter morphology ( J:125214 )

• in some males the ureter is connected to the vas deferens resulting in massive hydronephrosis

large ureter ( J:125214 )

• ureterovesical junctions associated with obstructions lead to megaureter and hydronephrosis

short ureter ( J:125214 )

abnormal ureterovesical junction morphology ( J:125214 )

• 7 of 10 mice exhibit bilateral ureterovesical junction defects, where one UVJ is typically located laterally and cephalad in the bladder (commonly associated with reflux in man) whereas the contralateral UVJ is located caudad in the bladder or even ectopically in the urethra

ureterovesical junction obstruction ( J:125214 )

• the caudal UVJ location is associated with obstruction, leading to megaureter and severe hydronephrosis

reproductive system

abnormal vas deferens morphology ( J:125214 )

♂ • in some males the ureter is connected to the vas deferens resulting in massive hydronephrosis

growth/size/body

kidney cyst ( J:125214 )

• kidney parenchyma is replaced by large cysts