Phenotypes Associated with This Genotype

Genotype
MGI:3759409

• Allelic Composition: Il2^tm1Hor/Il2^tm1Hor; Il4^tm1Cgn/Il4^tm1Cgn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased B cell proliferation ( J:16662 )

• B cells from lymph nodes have a larger size, and incorporate more BrdU indicating a faster proliferation rate

increased T cell proliferation ( J:16662 )

• 2-10 fold higher using in vivo incorporation of BrdU, which indicates a faster proliferation rate

immune system

increased B cell proliferation ( J:16662 )

• B cells from lymph nodes have a larger size, and incorporate more BrdU indicating a faster proliferation rate

increased T cell proliferation ( J:16662 )

• 2-10 fold higher using in vivo incorporation of BrdU, which indicates a faster proliferation rate

increased pro-B cell number ( J:16662 )

• found in bone marrow

increased pre-B cell number ( J:16662 )

• found in bone marrow

decreased IgG level ( J:16662 , J:26861 )

• there are decreased levels of viral specific antibodies 9 days after infection with lymphocytic choriomeningitis virus (J:16662)

• serum levels of IgG and IgE are close to normal in uninfected mice, compared to the high levels of these immunoglobulins found in mice with just the mutant Il2 locus (J:16662)

decreased cytotoxic T cell cytolysis ( J:26861 )

• there is a nine fold reduction of target cell killing by primary T cells in a chromium release assay

• there is no target cell killing by previously stimulated T cells in a chromium release assay

• footpad swelling is strongly reduced 6-10 days after infection with lymphocytic choriomeningitis virus

abnormal susceptibility to Riboviria infection ( J:26861 )

• despite reduced cytotoxic T cell activity, mice still eliminate lymphocytic choriomeningitis virus within nine days of infection

hematopoietic system

increased B cell proliferation ( J:16662 )

• B cells from lymph nodes have a larger size, and incorporate more BrdU indicating a faster proliferation rate

increased T cell proliferation ( J:16662 )

• 2-10 fold higher using in vivo incorporation of BrdU, which indicates a faster proliferation rate

increased pro-B cell number ( J:16662 )

• found in bone marrow

increased pre-B cell number ( J:16662 )

• found in bone marrow

decreased IgG level ( J:16662 , J:26861 )

• there are decreased levels of viral specific antibodies 9 days after infection with lymphocytic choriomeningitis virus (J:16662)

• serum levels of IgG and IgE are close to normal in uninfected mice, compared to the high levels of these immunoglobulins found in mice with just the mutant Il2 locus (J:16662)

decreased cytotoxic T cell cytolysis ( J:26861 )

• there is a nine fold reduction of target cell killing by primary T cells in a chromium release assay

• there is no target cell killing by previously stimulated T cells in a chromium release assay

• footpad swelling is strongly reduced 6-10 days after infection with lymphocytic choriomeningitis virus