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Phenotypes Associated with This Genotype
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice
• IPSC in response to GABA puff is increased relative to in wild-type mice
• IPSC strength is increased by about 50% relative to in wild-type mice

• spatial learning behavior in a Morris water maze is enhanced
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice
• response to a novel caged adult is decreased compared to in wild-type mice
• mice spend less time interacting with other mice compared to wild-type mice
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:125344

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory