Mouse Genome Informatics
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice
• IPSC in response to GABA puff is increased relative to in wild-type mice
• IPSC strength is increased by about 50% relative to in wild-type mice

• spatial learning behavior in a Morris water maze is enhanced
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice
• response to a novel caged adult is decreased compared to in wild-type mice
• mice spend less time interacting with other mice compared to wild-type mice
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse

Mouse Models of Human Disease
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:125344