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Phenotypes Associated with This Genotype
Genotype
MGI:3758961
Allelic
Composition
Nlgn3tm1Sud/Y
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlgn3tm1Sud mutation (1 available); any Nlgn3 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice (J:125344)
• IPSC in response to GABA puff is increased relative to in wild-type mice (J:125344)
• IPSC strength is increased by about 50% relative to in wild-type mice (J:125344)
• inhibitory postsynaptic currents (IPSCs) frequency is increased by 50% relative to in wild-type mice (J:125344)
• IPSC in response to GABA puff is increased relative to in wild-type mice (J:125344)
• IPSC strength is increased by about 50% relative to in wild-type mice (J:125344)

behavior/neurological
• spatial learning behavior in a Morris water maze is enhanced (J:125344)
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days (J:125344)
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice (J:125344)
• spatial learning behavior in a Morris water maze is enhanced (J:125344)
• mice exhibit an increase in ability to find hidden platform in a Morris water maze and a decrease in training days (J:125344)
• after training, mice cross to the precise location of the hidden platform almost twice as often as wild-type mice (J:125344)
• response to a novel caged adult is decreased compared to in wild-type mice (J:125344)
• mice spend less time interacting with other mice compared to wild-type mice (J:125344)
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse (J:125344)
• response to a novel caged adult is decreased compared to in wild-type mice (J:125344)
• mice spend less time interacting with other mice compared to wild-type mice (J:125344)
• however, locomotor activity, motor coordination, exploration of novel objects, and anxiety-related behaviors are normal and mice are capable of learning social interaction behaviors following repeated exposure to the same mouse (J:125344)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism, Susceptibility to, X-Linked 1; AUTSX1 300425 J:125344


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory