Phenotypes Associated with This Genotype

Genotype
MGI:3758909

• Allelic Composition: Inhba^tm1Zuk/Inhba^tm2Zuk
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:63882 )

• mice become cachectic and die between 3 and 4 weeks

reproductive system

decreased mature ovarian follicle number ( J:63882 )

♀ • in adult mice the number of preovulatory follicles is reduced compared to in wild-type mice

decreased secondary ovarian follicle number ( J:63882 )

♀ • ovaries contain fewer preantral follicles than in Inhba^tm2Zuk heterozygotes

small ovary ( J:63882 )

♀

abnormal seminiferous tubule morphology ( J:63882 )

♂ • differentiation of the seminiferous tubules is delayed

decreased testis weight ( J:63882 )

♂ • testis weight is decreased more substantially than in Inhba^tm2Zuk homozygotes

large penis ( J:63882 )

♂

enlarged clitoris ( J:63882 )

♀ • female mice have prominent os clitori

enlarged external male genitalia ( J:63882 )

♂ • some males have enlarged external genitalia and retracted foreskin

homeostasis/metabolism

hypoglycemia ( J:63882 )

• blood glucose level is reduced to 78.4+/-8 mg/dl compared to 129+/-7.8 mg/dl in wild-type mice

decreased circulating estradiol level ( J:63882 )

increased circulating follicle stimulating hormone level ( J:63882 )

• serum follicle stimulating hormone levels are 50% higher than those of wild-type mice

decreased circulating progesterone level ( J:63882 )

• serum progesterone levels are less than 50% of those in wild-type mice

hematopoietic system

anemia ( J:63882 )

• mild to moderate

decreased hematocrit ( J:63882 )

• 36+/-1.0% compared to 44+/-0.7% in wild-type mice

vision/eye

enophthalmos ( J:63882 )

growth/size/body

cachexia ( J:63882 )

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:63882 )

♀ • in adult mice the number of preovulatory follicles is reduced compared to in wild-type mice

decreased secondary ovarian follicle number ( J:63882 )

♀ • ovaries contain fewer preantral follicles than in Inhba^tm2Zuk heterozygotes

small ovary ( J:63882 )

♀

abnormal seminiferous tubule morphology ( J:63882 )

♂ • differentiation of the seminiferous tubules is delayed

decreased testis weight ( J:63882 )

♂ • testis weight is decreased more substantially than in Inhba^tm2Zuk homozygotes

renal/urinary system

large penis ( J:63882 )

♂

craniofacial

craniofacial phenotype ( J:63882 )

N • mice have normal palate and tooth development

integument

integument phenotype ( J:63882 )

N • mice have normal whisker development

retarded hair growth ( J:63882 )

sparse hair ( J:63882 )

• female mice have sparse perigenital hair

rough coat ( J:63882 )