Phenotypes Associated with This Genotype

Genotype
MGI:3758908

• Allelic Composition: Inhba^tm2Zuk/Inhba^tm2Zuk
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:63882 )

• 50% of mice die by week 26

reproductive system

decreased testis weight ( J:63882 )

♂ • testis weight is decreased to 50% of Inhba^tm2Zuk heterozygotes testis weight

large penis ( J:63882 )

♂

enlarged clitoris ( J:63882 )

♀ • female mice have prominent os clitori

enlarged external male genitalia ( J:63882 )

♂ • some males have enlarged external genitalia and retracted foreskin

delayed male fertility ( J:63882 )

• the onset of male fertility is delayed (31.7+/-2.5 days after mating pairs were established compared to 22+/-1.2 days for Inhba^tm2Zuk heterozygotes)

female infertility ( J:63882 )

♀ • only 1 of 6 females produced litters

homeostasis/metabolism

abnormal circulating hormone level ( J:63882 )

• dehydroepiandrosterone sulphate levels but not testosterone levels are increased in males and females

hematopoietic system

anemia ( J:63882 )

• mild

decreased hematocrit ( J:63882 )

• 40+/-2.3% compared to 44+/-0.7% in wild-type mice

vision/eye

enophthalmos ( J:63882 )

growth/size/body

decreased body size ( J:63882 )

endocrine/exocrine glands

decreased testis weight ( J:63882 )

♂ • testis weight is decreased to 50% of Inhba^tm2Zuk heterozygotes testis weight

renal/urinary system

large penis ( J:63882 )

♂

craniofacial

craniofacial phenotype ( J:63882 )

N • mice have normal palate and tooth development

integument

integument phenotype ( J:63882 )

N • mice have normal whisker development

retarded hair growth ( J:63882 )

short hair ( J:63882 )

sparse hair ( J:63882 )

• female mice have sparse perigenital hair

rough coat ( J:63882 )