Phenotypes Associated with This Genotype

Genotype
MGI:3758890

• Allelic Composition: Inhba^tm1Zuk/Inhba⁺; Inhbb^tm1Jae/Inhbb^tm1Jae
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased corpora lutea number ( J:125354 )

♀ • beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

female infertility ( J:125354 )

♀ • 3 of 11 females are infertile

reduced female fertility ( J:125354 )

♀ • the number of litters produced by females is reduced 43% (0.08+/-0.08 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

♀ • however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk females

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (.80+/-0.49 pups per litter compared to 7.78+/-0.48 pups per litter in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

♀ • beginning at 3 months of age and readily identifiable by 8 months of age, the number of corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to Inhba^tm1Zuk/Inhba^tm3Zuk mice