Phenotypes Associated with This Genotype

Genotype
MGI:3758887

• Allelic Composition: Amhr2^tm3(cre)Bhr/Amhr2⁺; Inhba^tm1Zuk/Inhba^tm3Zuk
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

increased corpora lutea number ( J:125354 )

♀ • at 8 months of age, the number of corpus luteums is increased compared to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

polyovular ovarian follicle ( J:125354 )

♀ • one follicle containing two oocytes at 3 months of age

reduced female fertility ( J:125354 )

♀ • the number of litters produced by females is reduced 43% (0.51+/-0.05 litters per month compared 0.89+/-0.04 litters per month in Inhba^tm1Zuk/Inhba^tm3Zuk mice)

♀ • however, there is no difference in the number of oocytes produced upon superovulation compared to Inhba^tm1Zuk/Inhba^tm3Zuk mice

decreased litter size ( J:125354 )

• the number of pups per litter is decreased 33% relative (5.19+/-0.65 pups per litter compared to 7.78+/-0.48 pups per litter in wild-type mice)

endocrine/exocrine glands

increased corpora lutea number ( J:125354 )

♀ • at 8 months of age, the number of corpus luteums is increased compared to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

♀ • the expression of a marker (Lhcgr) for healthy corpus luteums is increased relative to in Inhba^tm1Zuk/Inhba^tm3Zuk mice

polyovular ovarian follicle ( J:125354 )

♀ • one follicle containing two oocytes at 3 months of age