Phenotypes Associated with This Genotype

Genotype
MGI:3758815

• Allelic Composition: Comp^tm1Mbri/Comp⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased chondrocyte apoptosis ( J:125086 )

• the apoptosis rates for chondrocytes in the growth plate, proliferative zone and resting zone are increased by 1.8-fold and 9.8-fold, respectively, relative to apoptosis rates in wild-type mice

decreased chondrocyte proliferation ( J:125086 )

• proliferation of chondrocyte in the proliferative zone is decreased as indicated by a 12% reduction in bromodeoxyuridine-labelled chondrocytes relative to in wild-type mice

skeleton

increased chondrocyte apoptosis ( J:125086 )

• the apoptosis rates for chondrocytes in the growth plate, proliferative zone and resting zone are increased by 1.8-fold and 9.8-fold, respectively, relative to apoptosis rates in wild-type mice

decreased chondrocyte proliferation ( J:125086 )

• proliferation of chondrocyte in the proliferative zone is decreased as indicated by a 12% reduction in bromodeoxyuridine-labelled chondrocytes relative to in wild-type mice

short tibia ( J:125086 )

• by 9 weeks male mice tibia are 2% shorter than in wild-type mice

abnormal long bone epiphyseal plate proliferative zone ( J:125086 )

• the interterritorial matrix appears to contain less proteoglycan-like amorphous material than in wild-type mice making the collagen fibrils more prominent

abnormal pelvic girdle bone morphology ( J:125086 )

• mice exhibit mild pelvic deformation

limbs/digits/tail

short tibia ( J:125086 )

• by 9 weeks male mice tibia are 2% shorter than in wild-type mice