Phenotypes Associated with This Genotype

Genotype
MGI:3758615

• Allelic Composition: S100a9^tm1Nck/S100a9^tm1Nck
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cellular extravasation ( J:81642 )

• spontaneous migration of neutrophils in a in vitro transendothelial migration assay is increased relative to wild-type cells for 13.5% of neutrophils

• IL-8- and leukotriene B4- stimulated neutrophils in a in vitro transendothelial migration assay are only increased by 2.5- and 2.3-fold, respectively, compared to 3.8- and 6.1-fold, respectively, in wild-type cells

• however, polymorphonuclear neutrophil emigration into tissue is normal whether stimulated by IL-8 or thioglycolate

cellular

abnormal cellular extravasation ( J:81642 )

• spontaneous migration of neutrophils in a in vitro transendothelial migration assay is increased relative to wild-type cells for 13.5% of neutrophils

• IL-8- and leukotriene B4- stimulated neutrophils in a in vitro transendothelial migration assay are only increased by 2.5- and 2.3-fold, respectively, compared to 3.8- and 6.1-fold, respectively, in wild-type cells

• however, polymorphonuclear neutrophil emigration into tissue is normal whether stimulated by IL-8 or thioglycolate

hematopoietic system

abnormal cellular extravasation ( J:81642 )

• spontaneous migration of neutrophils in a in vitro transendothelial migration assay is increased relative to wild-type cells for 13.5% of neutrophils

• IL-8- and leukotriene B4- stimulated neutrophils in a in vitro transendothelial migration assay are only increased by 2.5- and 2.3-fold, respectively, compared to 3.8- and 6.1-fold, respectively, in wild-type cells

• however, polymorphonuclear neutrophil emigration into tissue is normal whether stimulated by IL-8 or thioglycolate