Phenotypes Associated with This Genotype

Genotype
MGI:3758614

• Allelic Composition: S100a9^tm1Nck/S100a9^tm1Nck
• Genetic Background: B6.129P2-S100a9^tm1Nck

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125179 )

• mice exhibit higher survival rates than wild-type mice when infected with 10⁴ colony forming units of Escherichia coli

immune system

decreased circulating tumor necrosis factor level ( J:125179 )

• 20 minutes after exposure to LPS-galactosamine, serum TNF-alpha levels are reduced more than 20-fold relative to similarly treated wild-type mice

decreased susceptibility to endotoxin shock ( J:125179 )

• following exposure to LPS-galactosamine, mice are less severely affected and survive longer than similarly treated wild-type mice

• mice fail to respond to LPS stimulation as determined by gene expression

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:125179 )

• mice exhibit higher survival rates than wild-type mice when infected with 10⁴ colony forming units of Escherichia coli

decreased susceptibility to fungal infection ( J:209808 )

• mice inoculated with Candida albicans exhibit a reduction in vaginal fungal burden compared to wild-type mice, however polymorphonuclear neutrophil migration to the vagina is similar to levels in wild-type mice

homeostasis/metabolism

decreased circulating tumor necrosis factor level ( J:125179 )

• 20 minutes after exposure to LPS-galactosamine, serum TNF-alpha levels are reduced more than 20-fold relative to similarly treated wild-type mice