Analysis Tools
immune system
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• the number of marginal zone B cells is increased by one third relative to in wild-type mice
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• total B cell number is reduced relative to wild-type mice
• the absolute number of CD19+ cells in the bone marrow, spleen and peritoneal cavity is two thirds of that observed in wild-type mice
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• the number of T3 B cells is reduced by half compared to in wild-type mice
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• the absolute number of B-1a B cells in the peritoneal cavity is half of that in wild-type mice
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• the absolute number of B-1b B cells in the peritoneal cavity is a quarter of that in wild-type mice
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• mature follicular B cells is reduced by half compared to in wild-type mice
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• the number of late pre-B cells is decreased by 30% relative to in wild-type mice
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• following exposure to NP-CGG, the anti-NP IgG response is diminished 3-fold relative to in wild-type mice
• following exposure to tetanus toxin (TT), the anti-TT IgG response is decreased 4-fold relative to in wild-type micefollowing exposure to tetanus toxin (TT), the anti-TT IgG response is decreased 4-fold relative to in wild-type mice
• however, the IgM response to TT is normal
• following intravenous alpha-1,3 dextran (DEX) challenge, IgM and Ig-lambda levels are lower than in similarly treated wild-type mice
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• following intravenous alpha-1,3 dextran (DEX) challenge, IgM and Ig-lambda levels are lower than in similarly treated wild-type mice
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hematopoietic system
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• the number of marginal zone B cells is increased by one third relative to in wild-type mice
|
|
• total B cell number is reduced relative to wild-type mice
• the absolute number of CD19+ cells in the bone marrow, spleen and peritoneal cavity is two thirds of that observed in wild-type mice
|
|
• the number of T3 B cells is reduced by half compared to in wild-type mice
|
|
• the absolute number of B-1a B cells in the peritoneal cavity is half of that in wild-type mice
|
|
• the absolute number of B-1b B cells in the peritoneal cavity is a quarter of that in wild-type mice
|
|
• mature follicular B cells is reduced by half compared to in wild-type mice
|
|
• the number of late pre-B cells is decreased by 30% relative to in wild-type mice
|
|
• following intravenous alpha-1,3 dextran (DEX) challenge, IgM and Ig-lambda levels are lower than in similarly treated wild-type mice
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