Phenotypes Associated with This Genotype

Genotype
MGI:3758491

• Allelic Composition: Gpr39^tm1Lex/Gpr39^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased lean body mass ( J:124913 )

• in male mice between 21 and 26 weeks of age, there is a slight but significant decrease in lean body mass (34.6% vs. 36.4% in wild-type mice)

increased body weight ( J:124913 )

• in mice over one year of age, there is a significant increase in body weight (48.06 g vs. 34.73 g in wild-type mice)

behavior/neurological

decreased compensatory feeding amount ( J:124913 )

• after fasting for 19 hours, food intake is decreased with greater differences occurring in mice over one year of age

• however, under ad libitum feeding, food intake in young (15 - 17 weeks of age) and old (85 weeks of age) mice is similar to wild-type controls

digestive/alimentary system

enlarged stomach ( J:124913 )

• male mice have larger stomachs as measured by weight (1395 mg vs. 978 mg for wild-type males)

abnormal digestion ( J:124913 )

• male mice under 17 weeks of age grind meal into fine particles significantly faster

excessive digestive secretion ( J:124913 )

• gastric secretion is increased almost 3 fold

• however, pH levels did not change

abnormal gastrointestinal motility ( J:124913 )

• gastric emptying is accelerated in male mice

abnormal large intestinal transit time ( J:124913 )

• more effective transit and expulsion of fecal pellets

homeostasis/metabolism

increased circulating cholesterol level ( J:124913 )

• cholesterol levels are increased in both fasted male and female mice

adipose tissue

increased percent body fat/body weight ( J:124913 )

• in male mice between 21 and 26 weeks of age, there is an increase in body fat percentage (17.8% vs. 12.7% in wild-type mice)