Phenotypes Associated with This Genotype

Genotype
MGI:3758450

• Allelic Composition: Rr158^tm1(Igh)Xu/Rr158^tm1(Igh)Xu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immune system morphology ( J:124407 )

• Igk rearrangement in pre-B cells is less efficient than in wild-type cells due to limited access to variable region segments

decreased B cell number ( J:124407 )

• total B cell number in the spleen and bone marrow is decreased by about 50% compared to in wild-type mice

• the number of kappa+ splenic B cells is reduced lowering the ratio of kappa to lambda B cells to 6:1 compared to 20:1 in wild-type mice

decreased immature B cell number ( J:124407 )

• the number of immature B cells (B220+IgM+IgD^low) is decreased relative to in wild-type mice

increased pre-B cell number ( J:124407 )

• the number of pre-B cells (B220+CD43-IgM-) is increased relative to in wild-type mice

hematopoietic system

decreased B cell number ( J:124407 )

• total B cell number in the spleen and bone marrow is decreased by about 50% compared to in wild-type mice

• the number of kappa+ splenic B cells is reduced lowering the ratio of kappa to lambda B cells to 6:1 compared to 20:1 in wild-type mice

decreased immature B cell number ( J:124407 )

• the number of immature B cells (B220+IgM+IgD^low) is decreased relative to in wild-type mice

increased pre-B cell number ( J:124407 )

• the number of pre-B cells (B220+CD43-IgM-) is increased relative to in wild-type mice