Analysis Tools
nervous system
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• kainic acid induces stronger seizures than in wild-type mice
• however, diazepam protects mice and wild-type mice similarly against kainic acid-induced seizures
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behavior/neurological
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• kainic acid induces stronger seizures than in wild-type mice
• however, diazepam protects mice and wild-type mice similarly against kainic acid-induced seizures
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• mutants exhibit a hyperphagic phenotype compared to controls on the first day of a novel palatable food test, and maintain the higher food intake over the course of the experiment
• mutants show high levels of physical interaction with a novel object from the first experimental day even when the palatability component is removed
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• mutants do not show any safety behavior towards the novel food and immediately consume the maximal amount, indicating impaired regulation of behavioral inhibition
• mutants exhibit shorter latencies to contact with the novel food item and to displace the novel object
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