Phenotypes Associated with This Genotype

Genotype
MGI:3758092

• Allelic Composition: Tg(Thy1-SNCA*A53T)9813Putt/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:63836 )

• on rotating rod, mice show an early onset, at >3 weeks of age, and progressive decline of motor performance

nervous system

astrocytosis ( J:63836 )

• astrocytic gliosis is observed in anterior horn of spinal cord and in some brain regions; microglial activation is also seen

abnormal motor neuron morphology ( J:63836 )

• some neurons in anterior horn show a Lewy-like pathology

motor neuron degeneration ( J:63836 )

• in all muscles examined, presynaptic motor neurons show signs of degeneration

abnormal neurite morphology ( J:63836 )

• neurites show heterogeneous changes including enlargements of proximal and distal neuritic segments, fine or thread-like inclusions, and beaded or spindle-shaped neurites

abnormal neuromuscular synapse morphology ( J:63836 )

• 10-40% of synapses are denervated in some mice and thinning of preterminal nerves, or swellings are detected in at least 50% of innervated synapses; denervation is observed in all muscles examined

alpha-synuclein inclusion body ( J:63836 )

• neurons in brain and some in spinal cord show accumulation of alpha-synuclein protein, similar to Lewy pathology in human brains

axon degeneration ( J:63836 )

• apparent in spinal roots; nerve fibers show breakdown

muscle

muscular atrophy ( J:63836 )

• muscle contains small angular fibers, indicating neurogenic atrophy