Phenotypes Associated with This Genotype

Genotype
MGI:3757575

• Allelic Composition: Abca3^tm1Dgen/Abca3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lung abnormalities in Abca3^tm1Dgen/Abca3⁺, and Abca3^tm1Dgen/Abca3^tm1Dgen mice

respiratory system

abnormal lung development ( J:124809 )

• some mice do not have well developed lungs

decreased alveolar lamellar body number ( J:124809 )

• at 6 months, mice have fewer lamellar bodies in their lungs than wild-type mice

abnormal surfactant physiology ( J:124809 )

• Sftpb staining is decreased as measured by immunohistochemistry but normal by western blot

• incorporation of radiolabeled substrates into newly synthesized disaturated phosphatidylcholine, phosphatidyl glycerol, phosphatidylethanolamine and phosphatidylserine in the lamellar bodies and surfactant is lower than in wild-type mice