Phenotypes Associated with This Genotype

Genotype
MGI:3757563

• Allelic Composition: Tg(RIP1-Tag)5Dh/?
• Genetic Background: C3HeB/FeJ-Tg(RIP1-Tag)5Dh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:80168 )

• up to 60% of islets show infiltration, accompanied by beta cell destruction

increased insulinoma incidence ( J:80168 )

• transgenic mice develop pancreatic beta cell tumors

pancreas inflammation ( J:80168 )

• lymphocytic infiltration of islets is detected by 14-15 weeks of age; infiltrates consist of CD4+ T cells , B cells and macrophages

• small mononuclear cells are detected adhering to walls of high endothelial venule-like vessels in areas of infiltration

immune system

pancreas inflammation ( J:80168 )

• lymphocytic infiltration of islets is detected by 14-15 weeks of age; infiltrates consist of CD4+ T cells , B cells and macrophages

• small mononuclear cells are detected adhering to walls of high endothelial venule-like vessels in areas of infiltration

neoplasm

increased insulinoma incidence ( J:80168 )

• transgenic mice develop pancreatic beta cell tumors