Phenotypes Associated with This Genotype

Genotype
MGI:3723643

• Allelic Composition: Park7^tm1Tmd/Park7^tm1Tmd
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cellular respiration ( J:125021 )

• in the brains of 3 to 4 and 18 to 24 month old mice, hydrogen peroxide production is increased 2-fold and succinate-supported hydrogen peroxide production is increased relative to in wild-type mice in an age-dependent manner with older mice producing more hydrogen peroxide

• in the brains of older mice, manganese superoxidase and mitochondrial glutathione peroxidase activity are increased

abnormal tricarboxylic acid cycle ( J:125021 )

• aconitase activity is reduced 60% in brain mitochondria relative to in wild-type mice

nervous system

nervous system phenotype ( J:125021 )

N • despite increased production of hydrogen peroxide in the brain, no defects in brain morphology or in the nigrostriatal pathway are detected