Phenotypes Associated with This Genotype

Genotype
MGI:3723640

• Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt; Tg(Pgk1-cre)1Lni/?
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125026 )

• mice die at birth

craniofacial

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

• mice are born with cleft secondary palate

endocrine/exocrine glands

absent parathyroid glands ( J:125026 )

abnormal thymus lobule morphology ( J:125026 )

• mice are born with missing thymic lobes

hearing/vestibular/ear

abnormal tympanic ring morphology ( J:125026 )

• mice are born with a hypoplastic tympanic ring

limbs/digits/tail

polydactyly ( J:125026 )

• mice are born with preaxial digit duplication

hematopoietic system

abnormal thymus lobule morphology ( J:125026 )

• mice are born with missing thymic lobes

behavior/neurological

aphagia ( J:125026 )

• mice die with no evidence of feeding

skeleton

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

immune system

abnormal thymus lobule morphology ( J:125026 )

• mice are born with missing thymic lobes

digestive/alimentary system

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

• mice are born with cleft secondary palate

growth/size/body

absent teeth ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

• mice are born with cleft secondary palate