Phenotypes for Crkl Tg(BCR/ABL)623Hkp MGI:3723274 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Crkl^tm1Hkp/Crkl^tm1Hkp Tg(BCR/ABL)623Hkp/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crkl^tm1Hkp mutation (1 available); any Crkl mutation (16 available)
Tg(BCR/ABL)623Hkp mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:76680 )

• average survival is 158 days

perinatal lethality, incomplete penetrance ( J:76680 )

• incomplete penetrance

neoplasm

increased leukemia incidence ( J:76680 )

• develop B-lineage leukemia to the same extent as mice expressing the transgene alone

increased B cell derived lymphoma incidence ( J:76680 )

• develop B-lineage lymphoma to the same extent as mice expressing the transgene alone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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