Phenotypes Associated with This Genotype

Genotype
MGI:3723204

• Allelic Composition: Cdk2^tm1Sgo/Cdk2^tm1Sgo; Cdk4^tm1Bbd/Cdk4^tm1Bbd; Cdk6^tm1Bbd/Cdk6^tm1Bbd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

embryonic lethality during organogenesis, incomplete penetrance ( J:124678 )

• mice begin to die around E13.5 and all are dying by E15.5

growth/size/body

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice

cardiovascular system

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

thin ventricular wall ( J:124678 )

• ventricular walls are thinner than in wild-type mice due to a decrease in the number of proliferating cardiomyocytes

cellular

decreased cell proliferation ( J:124678 )

• proliferation of mouse embryonic fibroblast cells is partially compromised

• exiting quiescence following serum treatment is delayed

liver/biliary system

liver hypoplasia ( J:124678 )

• between E12.5 and E13.5, livers exhibit a three-fold reduction in cellularity that is not accounted for by the decrease in embryo size

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:124678 )

• common myeloid progenitor cells are reduced 8-fold in number

muscle

decreased myocardial fiber number ( J:124678 )

• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls

embryo

decreased embryo size ( J:124678 )

• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice