Analysis Tools
mortality/aging
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• double homozygotes exhibit the same abnormalities as single homozygous Nog mutants
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nervous system
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• abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon
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exencephaly
(
J:74136
)
|
• in mutants where the frontal, parietal and interparietal bones are absent, the brain is exposed at birth
|
skeleton
|
• fusion of presphenoid, basisphenoid, and basioccipital bones
|
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• frontal bone is loose or absent
|
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• interparietal bones are loose or absent
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• occipital condyles are loose, showing variability in the distance separating them
|
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• parietal bone is loose or absent
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limbs/digits/tail
short limbs
(
J:74136
)
|
• truncated limbs
|
absent tail
(
J:74136
)
craniofacial
|
• fusion of presphenoid, basisphenoid, and basioccipital bones
|
|
• frontal bone is loose or absent
|
|
• interparietal bones are loose or absent
|
|
• occipital condyles are loose, showing variability in the distance separating them
|
|
• parietal bone is loose or absent
|
embryo
|
• abnormalities is neural tube closure, particularly in the brain vesicles between the diencephalons and myelencephalon
|
growth/size/body
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• frontal bone is loose or absent
|
