Phenotypes Associated with This Genotype

Genotype
MGI:3722918

• Allelic Composition: E2f1^tm1Meg/E2f1^tm1Meg; Rbl1^tm1Htr/Rbl1^tm1Htr; Tg(Pax6-cre,GFP)2Pgr/?
• Genetic Background: involves: 129 * C57BL/6 * FVB/N * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:124204 )

• Slc18a3 staining of mature starburst amacrine cells (SACs) is absent from the peripheral retina

• however, retinal transition cell division, rod cell numbers, retinal differentiation and rod function are normal

decreased retina ganglion cell number ( J:124204 )

• mice have slightly fewer ganglion cells at P0

abnormal amacrine cell morphology ( J:124204 )

• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis

• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer

• Slc18a3 staining of mature SACs is absent from the peripheral retina

• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice

abnormal retina bipolar cell morphology ( J:124204 )

• mice have slightly fewer bipolar cells at P18 or P30

• however, the proportion of bipolar cells is normal

abnormal retina inner plexiform layer morphology ( J:124204 )

• only 1 Calb2+ starburst amacrine cell track is detectable instead of 3 normally detected in the inner plexiform layer

thin retina outer nuclear layer ( J:124204 )

• the retinal outer nuclear layer is slightly reduced in thickness at P18 or P30

abnormal cone electrophysiology ( J:124204 )

• photopic response is very slightly reduced

nervous system

decreased retina ganglion cell number ( J:124204 )

• mice have slightly fewer ganglion cells at P0

abnormal amacrine cell morphology ( J:124204 )

• starburst amacrine cells (SACs) have defects in differentiation not associated with cell cycle or apoptosis

• only 1 Calb2+ SAC track is detectable instead of 3 normally detected in the inner plexiform layer

• Slc18a3 staining of mature SACs is absent from the peripheral retina

• 3.7% of Camk2a+ SAC express Chat and Slc18a3 compared to 60% in wild-type mice, 5.6% in Rbl1 null mice and 91% in Rbl1 and E2f3 null mice

abnormal retina bipolar cell morphology ( J:124204 )

• mice have slightly fewer bipolar cells at P18 or P30

• however, the proportion of bipolar cells is normal