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Phenotypes Associated with This Genotype
Genotype
MGI:3722846
Allelic
Composition
Pnliptm1Dyh/Pnliptm1Dyh
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnliptm1Dyh mutation (1 available); any Pnlip mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• triglyceride absorption is reduced (80.1+/- 3.6%) compared to wild-type (91.5 +/- 0.7%) mice when fed a Western-style diet (high fat)
• using a [14]C]tripalmitin tracer to determine the levels of triglycerides, long chain retinyl esters and cholesterol absorption, mice have 47% less [14]C] than in wild-type mice after 9 hours
• using [3]retinyl palmitate mixed in olive oil or in low fat chow, the rate and amount of retinyl ester absorption is reduced
• however, absorption of cholesteryl ester is normal
• when fed a high fat diet, cholesterol absorption is decreased
• mice weight less than wild-type counterparts after 10.5 weeks on a high fat diet
• when fed a high fat diet, fasting insulin levels are lower than in similarly treated wild-type mice
• when fed a high fat diet, plasma cholesterol levels are 36% less than in wild-type mice fed a high fat diet
• mice are more insulin resistant than wild-type mice and Celtm1Dyh homozygotes

liver/biliary system
• liver weight gain associated with consuming a high fat diet is reduced compared to in similarly treated wild-type mice

growth/size/body
• at 25 weeks of age, mice on a high fat diet have 6.7% more lean body mass than wild-type mice
• mice weight less than wild-type counterparts after 10.5 weeks on a high fat diet

adipose tissue
• at 25 weeks of age, mice on a high fat diet have 6.5% less body fat mass than wild-type mice

digestive/alimentary system
• triglyceride absorption is reduced (80.1+/- 3.6%) compared to wild-type (91.5 +/- 0.7%) mice when fed a Western-style diet (high fat)
• using a [14]C]tripalmitin tracer to determine the levels of triglycerides, long chain retinyl esters and cholesterol absorption, mice have 47% less [14]C] than in wild-type mice after 9 hours
• using [3]retinyl palmitate mixed in olive oil or in low fat chow, the rate and amount of retinyl ester absorption is reduced
• however, absorption of cholesteryl ester is normal
• when fed a high fat diet, cholesterol absorption is decreased


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory