Phenotypes Associated with This Genotype

Genotype
MGI:3722768

• Allelic Composition: Map2k3^tm1Flv/Map2k3^tm1Flv
• Genetic Background: B6.129S1-Map2k3^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124327 )

• following infection with live Streptococcus pneumoniae, 80% of mice are dead by day 5 and 100% at day 7 compared to 25% and 66% at the same time points for infected wild-type mice

• following infection with S. pneumoniae wild-type lysate and S. pneumoniae pneumolysin (PLY), mice begin to die within hours of infection and all mice are dead by 6 hours

immune system

increased susceptibility to bacterial infection ( J:124327 )

• following infection with live Streptococcus pneumoniae, 80% of mice are dead by day 5 and 100% at day 7 compared to 25% and 66% at the same time points for infected wild-type mice

• following infection with S. pneumoniae wild-type lysate and S. pneumoniae pneumolysin (PLY), mice begin to die within hours of infection and all mice are dead by 6 hours

• following infection with S. pneumoniae, mice exhibit more massive alveolar hemorrhage compared to infected wild-type mice