Phenotypes for Nlrp3 Slc11a1 MGI:3722761 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nlrp3^tm1Flv/Nlrp3^tm1Flv Slc11a1^s/Slc11a1^s
Genetic Background	B6.129S5-Nlrp3^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm1Flv mutation (1 available); any Nlrp3 mutation (66 available)
Slc11a1^s mutation (0 available); any Slc11a1 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1^s homozygotes

immune system

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1^s homozygotes

• when infected with 10⁵ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1^s homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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