Phenotypes Associated with This Genotype

Genotype
MGI:3722759

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del; Slc11a1^s/Slc11a1^s
• Genetic Background: B6.129S2-Casp1^tm1Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

immune system

cecum inflammation ( J:124378 )

• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption

increased susceptibility to bacterial infection ( J:124378 )

• when infected with 10⁵ Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

• when infected with 10⁶ Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased to a greater extent than in either single allele homozygote

• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1^s homozygotes

digestive/alimentary system

cecum inflammation ( J:124378 )

• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption