Phenotypes Associated with This Genotype

Genotype
MGI:3722626

• Allelic Composition: Cd79b^tm1Gzmn/Cd79b^tm1Gzmn
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-1a cell number ( J:124400 )

• the number of B-1a B cell is reduced five-fold relative to in wild-type mice

abnormal immune system physiology ( J:124400 )

• following exposure to NP-Ficcoll or NP-CGG (chicken gamma globulin), mice exhibit a small increase in IgG3 response to T-independent antibodies, no increase in proliferative responses to anti-IgM in vitro, and a slight decrease in T-dependent antibody responses

increased IgD level ( J:124400 )

• surface IgD levels on immature and recirculating B cells is increased

decreased IgG1 level ( J:124400 )

• IgG1 levels are decreased by five-fold relative to in wild-type mice

increased IgM level ( J:124400 )

• surface IgM levels on immature and recirculating B cells is increased

• IgM serum levels are increased three-fold relative to in wild-type mice

• following exposure to NP-Ficcoll or NP-CGG (chicken gamma globulin), NP-specific IgM antibodies are increased 10-fold

hematopoietic system

decreased B-1a cell number ( J:124400 )

• the number of B-1a B cell is reduced five-fold relative to in wild-type mice

increased IgD level ( J:124400 )

• surface IgD levels on immature and recirculating B cells is increased

decreased IgG1 level ( J:124400 )

• IgG1 levels are decreased by five-fold relative to in wild-type mice

increased IgM level ( J:124400 )

• surface IgM levels on immature and recirculating B cells is increased

• IgM serum levels are increased three-fold relative to in wild-type mice

• following exposure to NP-Ficcoll or NP-CGG (chicken gamma globulin), NP-specific IgM antibodies are increased 10-fold