Mouse Genome Informatics
ot
    Dmdtm1Mok/Y
involves: 129S/SvEv
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• at 4 and 4.5 months of age, the diaphragm exhibits an increase in connective tissue
• at 4 and 4.5 months of age, dissected muscles are whitish and hypertrophic
• several muscles exhibit an increase in size and an increase in connective tissue with necrotic fibers
• muscle degeneration is similar to that observed in other Dmd deficient mice

cellular
• in the plasma membrane of the extensor digitorum longus, caveola density is increased while the density of intramembranous particles is decreased

Mouse Models of Human Disease
OMIM IDRef(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:43164