Phenotypes Associated with This Genotype

Genotype
MGI:3722307

• Allelic Composition: Tg(APPSWE)2576Kha/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:43446 )

• after 1 backcross to C57BL/6 (or N1 generation), 1/3 mice die by <150 days of age; N2 generation mice show 36% lethality with median age at death of ~87 days, while in the N3 generation, 50% mortality is seen at median age of 65 days and in the N4 generation, 100% of mice die with median age of 65 days

postnatal lethality ( J:43446 )

• transmission of transgene decreases from expected 50% with each backcross generation, suggesting that there is pre-weaning or in utero lethality of transgenic mice; N2 generation mice crossed to (C57BL x SJL)F1 mice show restoration of expected 50% transmission and decreased early mortality (16% vs 36% in N2 generation)

behavior/neurological

behavior/neurological phenotype ( J:43446 )

N • Background Sensitivity: mice do not show obvious behavioral abnormalities