Phenotypes Associated with This Genotype

Genotype
MGI:3722248

• Allelic Composition: Tg(Pgk1-FGF2)16Cofn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased length of long bones ( J:33064 )

abnormal epiphyseal plate morphology ( J:33064 )

• similar to Tg(Pgk1-FGF2)15Cofn mice

abnormal long bone epiphyseal plate proliferative zone ( J:33064 )

• similar to Tg(Pgk1-FGF2)15Cofn mice

chondrodystrophy ( J:33064 )

• not as severe as seen in Tg(Pgk1-FGF2)15Cofn and Tg(Pgk1-FGF2)48Cofn mice

muscle

vascular smooth muscle hypertrophy ( J:33064 )

• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells

cardiovascular system

vascular smooth muscle hypertrophy ( J:33064 )

• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells

growth/size/body

megacephaly ( J:33064 )

• not as severe as seen in Tg(Pgk1-FGF2)15Cofn and Tg(Pgk1-FGF2)48Cofn mice