Phenotypes Associated with This Genotype

Genotype
MGI:3722247

• Allelic Composition: Tg(Pgk1-FGF2)15Cofn/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:33064 )

• both sexes show displacement of weight gain during growth from weaning to 50 days of age; females remain smaller than nontransgenic littermates, whereas males have similar body weights to controls at 50 days of age

megacephaly ( J:33064 )

• severe

craniofacial

abnormal neurocranium morphology ( J:33064 )

• calvaria are enlarged over occipital bones

limbs/digits/tail

short humerus ( J:33064 )

short radius ( J:33064 )

abnormal ulna morphology ( J:33064 )

• ulna shows unusual angle of bending

short ulna ( J:33064 )

short femur ( J:33064 )

skeleton

abnormal neurocranium morphology ( J:33064 )

• calvaria are enlarged over occipital bones

abnormal ulna morphology ( J:33064 )

• ulna shows unusual angle of bending

decreased length of long bones ( J:33064 )

• 20-30% shortening of ulna, radius, humerus, femur, and tibia, relative to controls

short humerus ( J:33064 )

short radius ( J:33064 )

short ulna ( J:33064 )

short femur ( J:33064 )

abnormal rib development ( J:33064 )

• ribs adjacent to thoracic vertebrae are enlarged and flattened at proximal and distal ends

abnormal thoracic vertebrae morphology ( J:33064 )

• appear enlarged and misshapen

abnormal cervical vertebrae morphology ( J:33064 )

• cervical vertebrae appear compressed, with surface irregularities

chondrodystrophy ( J:33064 )

• significant differences are observed between transgenic mice and controls for bone length per gram body weight

muscle

vascular smooth muscle hypertrophy ( J:33064 )

• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells

cardiovascular system

vascular smooth muscle hypertrophy ( J:33064 )

• smooth muscle cells are hypertrophic compared to control cells, with 66% more protein content than control cells