Phenotypes Associated with This Genotype

Genotype
MGI:3722179

• Allelic Composition: Dab1^tm2Cpr/Dab1^tm2Cpr
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:79475 )

• mice die at day 20 to 30 of unidentified causes

nervous system

abnormal brain morphology ( J:79475 )

• the cerebral cortex, hippocampus and cerebellum exhibit defects

abnormal cortical marginal zone morphology ( J:79475 )

• the cortical marginal zone is occupied with many cells unlike in wild-type mice

• the intermediate plexiform zone proximal to the pial surface contains ectopic nerve tracts

absent cerebellar foliation ( J:79475 )

abnormal hippocampus CA2 region morphology ( J:79475 )

• only two or three wavy lamina form

abnormal dentate gyrus morphology ( J:79475 )

• the granule cells in the dentate gyrus are disorganized

abnormal cerebral cortex morphology ( J:79475 )

• the six layers of the cerebral cortex are disorganized

abnormal cerebellar Purkinje cell layer ( J:79475 )

• the Purkinje cell layers are organized into internal clusters

abnormal cerebellar granule layer morphology ( J:79475 )

• the cerebellar granule cells are found in a less organized layer than in wild-type mice and are excluded from the external limits of the cerebellum by a thin molecular layer

small cerebellum ( J:79475 )

• the cerebellum is one fifth the size of that in normal mice

behavior/neurological

ataxia ( J:79475 )

• mice display ataxia that is characterized by frequent loss of balance, tremulous locomotion, tendency to drag hind limbs and hyperextension of the tail

impaired balance ( J:79475 )

abnormal tail movements ( J:79475 )

• ataxic mice often display hyperextension of the tail