Analysis Tools
mortality/aging
|
• Background Sensitivity: 20/52 mice die before 120 days, 3/52 by 130 days and 3/52 die after 250 days; 50% survive for at least a year
|
behavior/neurological
|
• mice show impairment in acquisition of spatial information during place discrimination training at 11 weeks of age; mice show longer latencies to reach escape platform and longer search paths to reach platform
|
|
• during probe trial after completion of training, mice display lower annulus crossing index, searching for platform in a circular fashion and often crossing the centers of alternative quadrants, relative to non-transgenic controls
|
nervous system
| N |
• no differences are seen in volume of dorsal hippocampus or in neuronal cytoarchitecture between transgenic and control mice
|
|
• dense-cored amyloid deposits contain amyloid beta-42 peptide
(J:69967)
• 14-month old mutants show dense amyloid beta core plaques in the hippocampus
(J:166801)
|
|
• by 101 days, plaques are detected within the pial vessels, and in the cerebral vasculature by 196 days
|
astrocytosis
(
J:69967
)
|
• amyloid plaques are associated with dystrophic neurites; dystrophic neuron pathology increases with age and frequency of large cored plaques
|
homeostasis/metabolism
amyloidosis
(
J:69967
)
|
• potent deposition of cerebral amyloid is observed in all mice 90 days of age
|
|
• dense-cored amyloid deposits contain amyloid beta-42 peptide
(J:69967)
• 14-month old mutants show dense amyloid beta core plaques in the hippocampus
(J:166801)
|
|
• by 101 days, plaques are detected within the pial vessels, and in the cerebral vasculature by 196 days
|
|
• increase in creatine deposits in the hippocampal gray matter as mutants age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:166801 | ||
