Phenotypes Associated with This Genotype

Genotype
MGI:3722145

• Allelic Composition: Hoxb2^tm1Fmr/Hoxb2^tm1Fmr
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:54652 )

• 22 of the 60 mice that survived to weaning die between 3 weeks and 2 months

neonatal lethality, incomplete penetrance ( J:54652 )

• 82% of mice die around birth

postnatal lethality, incomplete penetrance ( J:54652 )

• only 60 of 1073 mice survive to weaning

nervous system

abnormal rhombomere 4 morphology ( J:54652 )

• r4 exhibits characteristics of r2

rhombomere transformation ( J:54652 )

• r4 exhibits characteristics of r2

absent facial nuclei ( J:54652 )

• at E13.5, facial motor nucleus are absent in 5 of 5 mice

behavior/neurological

abnormal maternal nurturing ( J:54652 )

♀ • females that survive and reproduce have difficulties raising their pups

embryo

abnormal rhombomere 4 morphology ( J:54652 )

• r4 exhibits characteristics of r2

rhombomere transformation ( J:54652 )

• r4 exhibits characteristics of r2