Mouse Genome Informatics
involves: CF-1
phenotype observed in females
phenotype observed in males
N normal phenotype
• bilateral club foot deformity at birth with no clinical progression (J:8195)

• chronic paralysis with tetrodotoxin causes no further depression of primary myotube numbers but secondary myotube numbers are reduced by 40% (J:4724)
• muscle fibers in the tibialis anterior and extensor digitorum longus (EDL) muscles at 30 days of age are smaller in bulk and have fewer numbers of muscle fibers, all of which are of smaller caliber (J:8195)
• myofibrils are poorly organized, especially in the small-caliber fibers (J:8195)
• EDL muscles have a greater number of primary myotubes than controls at E12-13 but by E15, almost half of them degenerate (J:8195)
• in newborns, the number of secondary myotubes in EDL muscles is 60% of control numbers and by 4 weeks of age, massive muscle atrophy and degeneration sets in (J:8195)
• muscle fibers are less tightly packed, resulting in ovoid rather than polygonal cells (J:8195)
• exhibit postnatal degeneration of muscle which results in the adult phenotype of a few very attenuated fibers interspersed with large amounts of fat and connective tissue
• neurogenic muscular atrophy in the peroneal muscle group (J:8195)
• muscles in the anterolateral hind legs, including tibialis anterior, extensor digitorum longus, extensor hallucis longus, and fourth and fifth tibial muscles are atrophic and reduced to fibrous strings (J:8195)

nervous system
• the peroneal and saphenous nerves are entirely absent (J:4723)
• however, the sciatic, tibial, sural, and other peripheral nerves appear normal (J:8195)
• primary myotubes develop in aneural muscles but require innervation for postnatal maintenance, while secondary myotube development is not dependent upon innervation (J:4723)
• lack innervation to the peroneal muscle group due to absence of the common peroneal nerve branch (J:8195)

• unusual gait due to the dropped foot (J:6590)

• ankle joint is immobile by the time of birth

• growth is slightly delayed

Mouse Models of Human Disease
Arthrogryposis Multiplex Congenita, Neurogenic Type; AMCN 208100 J:8195
Clubfoot, Congenital, with or without Deficiency of Long Bones and/or Mirror-Image Polydactyly; CCF 119800 J:8195