Phenotypes Associated with This Genotype

Genotype
MGI:3722143

• Allelic Composition: Tg(Thy1-APPLon)2Vln/0; Tg(Thy1-BACE1)16Vln/0
• Genetic Background: involves: C57BL/6 * DBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:93635 )

• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics

cerebral amyloid angiopathy ( J:93635 )

• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals

abnormal subiculum morphology ( J:93635 )

• by 15 months, subiculum is almost totally covered with diffuse and senile plaques

abnormal cerebral cortex morphology ( J:93635 )

• at 15 months and older, surface of cerebral cortex is occupied by thioflavin-S- and amyloid beta-positive deposits is 3-5-fold greater than in age-matched Tg(APPV717I)1130Kha mice

abnormal neurite morphology ( J:93635 )

• dystrophic neurites with swollen and distorted neuritic profiles are identified in brains of mice

homeostasis/metabolism

amyloidosis ( J:93635 )

• total levels of intact amyloid beta-40 and-42 peptides are increased by ~3-fold in older mice relative to single transgenic mice

amyloid beta deposits ( J:93635 )

• fibrillar thioflavin-S positive amyloid plaques are significantly increased in subiculum region of brain compared to Tg(APPV717I)1130Kha single transgenics

cerebral amyloid angiopathy ( J:93635 )

• decrease in vascular amyloid deposition is found in double transgenics relative to single mutant animals

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:93635