Phenotypes Associated with This Genotype

Genotype
MGI:3722106

• Allelic Composition: Cd1d1^tm1Crw/Cd1d1^tm1Crw
• Genetic Background: B6.129S4-Cd1d1^tm1Crw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased IgG level ( J:99107 )

• levels of anti CII IgG antibodies are reduced compared to in wild-type mice

decreased susceptibility to induced arthritis ( J:99107 )

• following induction of arthritis with collagen (CIA) the incidence (40%) and arthritis score (2.0+/-2.7) is reduced compared to wild-type mice (90% incidence with a score of 5.4+/-3.2)

skeleton

decreased susceptibility to induced arthritis ( J:99107 )

• following induction of arthritis with collagen (CIA) the incidence (40%) and arthritis score (2.0+/-2.7) is reduced compared to wild-type mice (90% incidence with a score of 5.4+/-3.2)

hematopoietic system

decreased IgG level ( J:99107 )

• levels of anti CII IgG antibodies are reduced compared to in wild-type mice