Mouse Genome Informatics
cx
    Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)2Vln/Tg(Thy1-MAPT)2Vln

involves: FVB
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex
• double mutants are unable to remain on the rotating rod

nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~10-fold compared to Tg(Thy1-MAPT)2Vln homozygotes in spinal cord and cerebral cortex
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes

muscle
N
• quadriceps is normal and devoid of any muscle wasting

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:100971