Mouse Genome Informatics
cx
    Tg(GSK3B*S9A)1Vln/0
Tg(Thy1-MAPT)1Vln/Tg(Thy1-MAPT)1Vln

involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• mice show equal performance to wild-type in the hanging grid test and forced swim test, and show almost no impairment of the righting reflex (J:100971)
• double mutants are unable to remain on the rotating rod

nervous system
• in 3-month old mice, dilated axons are observed, but numbers are reduced ~5-fold in spinal cord and ~20-fold in cerebral cortex compared to Tg(Thy1-MAPT)1Vln homozygotes
• axonal dystrophic changes are dramatically reduced in mice expressing both transgenes

muscle
N
• quadriceps is normal and devoid of any muscle wasting (J:100971)

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:100971