Phenotypes for Dnmt3a Dnmt3b MGI:3722085 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Dnmt3a^tm2Enl/Dnmt3a^tm2Enl Dnmt3b^tm1Enl/Dnmt3b^tm1Enl
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3a^tm2Enl mutation (1 available); any Dnmt3a mutation (138 available)
Dnmt3b^tm1Enl mutation (1 available); any Dnmt3b mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal DNA methylation ( J:116773 )

• the methylation levels of E8.5 and E9.5 embryos are lower than in wild-type embryos of the same stage and resembles wild-type blastocyst levels of methylation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23