Phenotypes Associated with This Genotype

Genotype
MGI:3722084

• Allelic Composition: Tg(Eno2CDK5R1)1Jdm/?
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:82825 )

• mice show increased open-field locomotor activity, which is 2-fold greater than wild-type at 16 weeks and increased locomotor activity in activity chambers

• in elevated-plus maze, mice aged 9-12 weeks spend more time on the open arms compared to wild-type animals

tremors ( J:82825 )

• 4-9 week-old mice display whole-body exertion tremors

abnormal locomotor behavior ( J:82825 )

• starting at 5-7 weeks of age, mice show increased open-field locomotor activity, which is 2-fold greater than wild-type at 16 weeks

nervous system

abnormal axon morphology ( J:82825 )

• axonal swelling is observed in neurons in the amygdala and spinal cord of 3- to 6-month old mice; affected axoplasm is filled with numerous abnormally clustered mitochondria and lysosomes, and skeletal components are disorganized