Phenotypes Associated with This Genotype

Genotype
MGI:3722061

• Allelic Composition: Dync1h1^Loa/Dync1h1⁺
• Genetic Background: C3H/HeH-Dync1h1^Loa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:83128 )

• at E13.5, nerves extend less far into the limb and exhibit a 30% decrease in branching complexity

decreased motor neuron number ( J:83128 )

• alpha motor neurons in the spinal cord anterior horn are decreased in number at 16 and 19 months

motor neuron degeneration ( J:83128 )

behavior/neurological

impaired coordination ( J:83128 )

• authors state that mice display a similar phenotype as Dync1h1^Cra1 heterozygotes

abnormal grip strength ( J:83128 )

• authors state that mice display a similar phenotype as Dync1h1^Cra1 heterozygotes

muscle

muscle spasm ( J:83128 )

• mice exhibit cramping when hung by their tails in which the whole body would start to tremble, then the forelimbs cramped, the neck stretched, the mouth opened and the tongue stuck out

• Background Sensitivity: cramping is more severe than on a mixed C57BL/6 background